TargetNet
  Target name

P23946: Chymase

  Protein function

Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.

  Database links
Uniprot primary ID P23946
PDB ID 3S0N 4AFU 4AFS 4AG1 4AFQ 1T31 1KLT 4KP0 4AFZ 4K5Z 4K60 2HVX 1NN6 4K2Y 4K69 3N7O 4AG2 1PJP
DrugBank ID
BioGrid ID 107624
GuidetoPHARMACOLOGY ID 2340
PharmGKB ID PA26623
KEGG ID hsa:1215
DIP ID
STRING ID 9606.ENSP00000250378
IntAct ID
DMDM 126825
BRENDA 3.4.21.39
Reactome R-HSA-1592389 R-HSA-2022377 R-HSA-1433557
SignaLink
BioCyc
Entrez Gene (Gene ID) 1215
BindingDB P23946
  Model Performance Metrics
Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.914 0.005 0.914 0.006 0.914 0.005 0.914 0.005 0.970 0.000 0.825 0.008 Download
Estate fingerprints 0.875 0.011 0.643 0.007 0.759 0.006 0.786 0.007 0.839 0.003 0.535 0.011 Download
MACCS fingerprints 0.884 0.005 0.822 0.007 0.853 0.005 0.857 0.005 0.920 0.000 0.706 0.007 Download
Daylight fingerprints 0.797 0.005 0.815 0.006 0.806 0.005 0.805 0.005 0.819 0.003 0.615 0.005 Download
ECFP2 fingerprints 0.958 0.004 0.942 0.005 0.950 0.000 0.950 0.000 0.990 0.000 0.900 0.005 Download
ECFP4 fingerprints 0.950 0.000 0.970 0.000 0.960 0.000 0.960 0.000 0.990 0.000 0.921 0.003 Download
ECFP6 fingerprints 0.940 0.000 0.994 0.000 0.967 0.005 0.963 0.005 0.990 0.000 0.930 0.000 Download
  Download datasets
Positive dataset Negative dataset

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 E-mail: biomed@csu.edu.cn