TargetNet
  Target name

P24468: COUP transcription factor 2

  Protein function

Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A.

  Database links
Uniprot primary ID P24468
PDB ID 3CJW
DrugBank ID
BioGrid ID 112884
GuidetoPHARMACOLOGY ID
PharmGKB ID PA31759
KEGG ID hsa:7026
DIP ID DIP-29713N
STRING ID 9606.ENSP00000377721
IntAct ID P24468
DMDM 114203
BRENDA
Reactome R-HSA-381340
SignaLink P24468
BioCyc
Entrez Gene (Gene ID) 7026
BindingDB P24468
  Model Performance Metrics
Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.613 0.019 0.713 0.021 0.663 0.009 0.646 0.011 0.749 0.010 0.328 0.018 Download
Estate fingerprints 0.707 0.015 0.635 0.008 0.671 0.009 0.682 0.009 0.718 0.009 0.343 0.017 Download
MACCS fingerprints 0.613 0.014 0.673 0.010 0.643 0.009 0.633 0.009 0.690 0.007 0.287 0.018 Download
Daylight fingerprints 0.643 0.022 0.701 0.013 0.672 0.011 0.664 0.014 0.734 0.010 0.349 0.023 Download
ECFP2 fingerprints 0.796 0.022 0.666 0.008 0.731 0.012 0.747 0.015 0.825 0.007 0.465 0.025 Download
ECFP4 fingerprints 0.808 0.018 0.700 0.009 0.754 0.010 0.769 0.009 0.847 0.005 0.513 0.020 Download
ECFP6 fingerprints 0.749 0.016 0.731 0.015 0.740 0.013 0.741 0.015 0.835 0.008 0.476 0.029 Download
  Download datasets
Positive dataset Negative dataset

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 E-mail: biomed@csu.edu.cn