Target name

P24530: Endothelin B receptor


  Protein function

Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

  Database links

Uniprot primary ID P24530
PDB ID
DrugBank ID DB08932 DB00559 DB06268
BioGrid ID 108232
GuidetoPHARMACOLOGY ID 220
PharmGKB ID PA27618
KEGG ID hsa:1910
DIP ID
STRING ID 9606.ENSP00000366416
IntAct ID P24530
DMDM 119622
BRENDA
Reactome R-HSA-375276 R-HSA-416476
SignaLink P24530
BioCyc
Entrez Gene (Gene ID) 1910
BindingDB P24530

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.904 0.005 0.992 0.000 0.948 0.004 0.941 0.003 0.990 0.000 0.894 0.005 Download
Estate fingerprints 0.891 0.003 0.789 0.003 0.840 0.000 0.850 0.000 0.920 0.000 0.685 0.005 Download
MACCS fingerprints 0.931 0.003 0.863 0.005 0.897 0.005 0.900 0.000 0.950 0.000 0.796 0.005 Download
Daylight fingerprints 0.889 0.003 0.833 0.000 0.861 0.003 0.867 0.005 0.910 0.000 0.726 0.005 Download
ECFP2 fingerprints 0.970 0.000 0.970 0.000 0.970 0.000 0.970 0.000 0.990 0.000 0.938 0.004 Download
ECFP4 fingerprints 0.970 0.000 0.990 0.000 0.980 0.000 0.980 0.000 0.990 0.000 0.960 0.000 Download
ECFP6 fingerprints 0.961 0.003 0.995 0.005 0.978 0.004 0.977 0.005 0.990 0.000 0.950 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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