Target name

P24557: Thromboxane-A synthase


  Protein function

endoplasmic reticulum membrane, arachidonic acid metabolic process, cyclooxygenase pathway, icosanoid metabolic process, small molecule metabolic process, xenobiotic metabolic process

  Database links

Uniprot primary ID P24557
PDB ID
DrugBank ID DB00795 DB01207
BioGrid ID 112778
GuidetoPHARMACOLOGY ID
PharmGKB ID PA349
KEGG ID hsa:6916
DIP ID
STRING ID
IntAct ID P24557
DMDM
BRENDA
Reactome R-HSA-5579032 R-HSA-211979 R-HSA-2162123
SignaLink
BioCyc MetaCyc:HS00728-MONOMER
Entrez Gene (Gene ID) 6916
BindingDB P24557

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.879 0.003 0.961 0.005 0.920 0.000 0.919 0.003 0.971 0.003 0.845 0.005 Download
Estate fingerprints 0.888 0.006 0.932 0.000 0.910 0.000 0.908 0.004 0.960 0.000 0.819 0.006 Download
MACCS fingerprints 0.834 0.005 0.964 0.000 0.899 0.003 0.890 0.000 0.960 0.000 0.800 0.005 Download
Daylight fingerprints 0.740 0.000 0.818 0.005 0.779 0.003 0.770 0.000 0.810 0.000 0.558 0.004 Download
ECFP2 fingerprints 0.960 0.000 0.982 0.000 0.971 0.003 0.971 0.003 0.990 0.000 0.950 0.000 Download
ECFP4 fingerprints 0.970 0.000 0.990 0.000 0.980 0.000 0.980 0.000 0.999 0.003 0.960 0.000 Download
ECFP6 fingerprints 0.960 0.000 0.998 0.000 0.979 0.003 0.979 0.003 1.000 0.000 0.952 0.004 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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