Target name

P25021: Histamine H2 receptor


  Protein function

The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity).

  Database links

Uniprot primary ID P25021
PDB ID
DrugBank ID DB00751 DB00501 DB00863 DB01142 DB00667 DB00927 DB08806
BioGrid ID
GuidetoPHARMACOLOGY ID 263
PharmGKB ID PA29457
KEGG ID hsa:3274
DIP ID
STRING ID 9606.ENSP00000366506
IntAct ID
DMDM 123120
BRENDA
Reactome R-HSA-418555 R-HSA-390650
SignaLink
BioCyc
Entrez Gene (Gene ID) 3274
BindingDB P25021

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.798 0.008 0.816 0.010 0.807 0.007 0.806 0.005 0.894 0.005 0.616 0.012 Download
Estate fingerprints 0.778 0.021 0.620 0.013 0.699 0.015 0.721 0.016 0.756 0.005 0.402 0.033 Download
MACCS fingerprints 0.823 0.007 0.751 0.010 0.787 0.007 0.796 0.005 0.886 0.005 0.579 0.011 Download
Daylight fingerprints 0.815 0.005 0.805 0.000 0.810 0.000 0.810 0.000 0.836 0.005 0.614 0.005 Download
ECFP2 fingerprints 0.864 0.012 0.886 0.015 0.875 0.011 0.873 0.011 0.939 0.003 0.750 0.019 Download
ECFP4 fingerprints 0.841 0.014 0.927 0.008 0.884 0.008 0.878 0.011 0.943 0.005 0.769 0.020 Download
ECFP6 fingerprints 0.788 0.010 0.950 0.007 0.869 0.003 0.857 0.005 0.933 0.005 0.745 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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