Target name

P25024: C-X-C chemokine receptor type 1


  Protein function

Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.

  Database links

Uniprot primary ID P25024
PDB ID 2LNL 1ILP 1ILQ
DrugBank ID DB01009
BioGrid ID 109791
GuidetoPHARMACOLOGY ID 68
PharmGKB ID PA29842
KEGG ID hsa:3577
DIP ID DIP-3779N
STRING ID 9606.ENSP00000295683
IntAct ID P25024
DMDM 108936015
BRENDA
Reactome R-HSA-418594 R-HSA-380108
SignaLink
BioCyc
Entrez Gene (Gene ID) 3577
BindingDB P25024

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.761 0.010 0.999 0.000 0.880 0.007 0.863 0.005 0.980 0.000 0.782 0.009 Download
Estate fingerprints 0.854 0.005 0.888 0.009 0.871 0.003 0.871 0.003 0.940 0.000 0.743 0.007 Download
MACCS fingerprints 0.855 0.007 0.983 0.003 0.919 0.003 0.913 0.005 0.950 0.000 0.842 0.006 Download
Daylight fingerprints 0.730 0.000 0.992 0.000 0.861 0.003 0.841 0.003 0.907 0.005 0.760 0.000 Download
ECFP2 fingerprints 0.874 0.007 1.000 0.000 0.938 0.004 0.932 0.006 0.980 0.000 0.881 0.007 Download
ECFP4 fingerprints 0.878 0.006 1.000 0.000 0.940 0.000 0.934 0.005 0.990 0.000 0.884 0.005 Download
ECFP6 fingerprints 0.881 0.003 0.999 0.000 0.940 0.000 0.937 0.005 0.990 0.000 0.887 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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