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E-mail: biomed@csu.edu.cn
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Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.
| Uniprot primary ID | P25024 |
| PDB ID | 2LNL 1ILP 1ILQ |
| DrugBank ID | DB01009 |
| BioGrid ID | 109791 |
| GuidetoPHARMACOLOGY ID | 68 |
| PharmGKB ID | PA29842 |
| KEGG ID | hsa:3577 |
| DIP ID | DIP-3779N |
| STRING ID | 9606.ENSP00000295683 |
| IntAct ID | P25024 |
| DMDM | 108936015 |
| BRENDA | |
| Reactome | R-HSA-418594 R-HSA-380108 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 3577 |
| BindingDB | P25024 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.761 | 0.010 | 0.999 | 0.000 | 0.880 | 0.007 | 0.863 | 0.005 | 0.980 | 0.000 | 0.782 | 0.009 | Download |
| Estate fingerprints | 0.854 | 0.005 | 0.888 | 0.009 | 0.871 | 0.003 | 0.871 | 0.003 | 0.940 | 0.000 | 0.743 | 0.007 | Download |
| MACCS fingerprints | 0.855 | 0.007 | 0.983 | 0.003 | 0.919 | 0.003 | 0.913 | 0.005 | 0.950 | 0.000 | 0.842 | 0.006 | Download |
| Daylight fingerprints | 0.730 | 0.000 | 0.992 | 0.000 | 0.861 | 0.003 | 0.841 | 0.003 | 0.907 | 0.005 | 0.760 | 0.000 | Download |
| ECFP2 fingerprints | 0.874 | 0.007 | 1.000 | 0.000 | 0.938 | 0.004 | 0.932 | 0.006 | 0.980 | 0.000 | 0.881 | 0.007 | Download |
| ECFP4 fingerprints | 0.878 | 0.006 | 1.000 | 0.000 | 0.940 | 0.000 | 0.934 | 0.005 | 0.990 | 0.000 | 0.884 | 0.005 | Download |
| ECFP6 fingerprints | 0.881 | 0.003 | 0.999 | 0.000 | 0.940 | 0.000 | 0.937 | 0.005 | 0.990 | 0.000 | 0.887 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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