Details-Calcnet-TargetNet

Target name

P25025: C-X-C chemokine receptor type 2

Protein function

Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.

Database links

Uniprot primary ID	P25025
PDB ID	4Q3H
DrugBank ID
BioGrid ID	109793
GuidetoPHARMACOLOGY ID	69
PharmGKB ID	PA29843
KEGG ID	hsa:3579
DIP ID	DIP-3782N
STRING ID	9606.ENSP00000319635
IntAct ID	P25025
DMDM	1352454
BRENDA
Reactome	R-HSA-418594 R-HSA-380108
SignaLink	P25025
BioCyc
Entrez Gene (Gene ID)	3579
BindingDB	P25025

Model Performance Metrics

Fingerprint type	Sensitivity	SEN_std	Specificity	SPE_std	Accuracy	ACC_std	F1-score	F1-score_std	AUC	AUC_std	MCC	MCC_std	Download model
FP2 fingerprints	0.760	0.000	1.000	0.000	0.880	0.000	0.860	0.000	0.980	0.000	0.780	0.000	Download
Estate fingerprints	0.819	0.003	0.823	0.010	0.821	0.006	0.821	0.003	0.884	0.005	0.645	0.008	Download
MACCS fingerprints	0.807	0.005	0.907	0.005	0.857	0.005	0.851	0.003	0.920	0.000	0.718	0.006	Download
Daylight fingerprints	0.713	0.005	0.987	0.000	0.850	0.000	0.830	0.000	0.930	0.000	0.738	0.004	Download
ECFP2 fingerprints	0.913	0.005	0.971	0.004	0.942	0.004	0.942	0.004	0.990	0.000	0.892	0.004	Download
ECFP4 fingerprints	0.949	0.003	0.991	0.005	0.970	0.000	0.970	0.000	1.000	0.000	0.949	0.003	Download
ECFP6 fingerprints	0.942	0.004	0.998	0.005	0.970	0.000	0.970	0.000	1.000	0.000	0.942	0.004	Download

Download datasets

Positive dataset

Negative dataset