Target name

P25025: C-X-C chemokine receptor type 2


  Protein function

Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.

  Database links

Uniprot primary ID P25025
PDB ID 4Q3H
DrugBank ID
BioGrid ID 109793
GuidetoPHARMACOLOGY ID 69
PharmGKB ID PA29843
KEGG ID hsa:3579
DIP ID DIP-3782N
STRING ID 9606.ENSP00000319635
IntAct ID P25025
DMDM 1352454
BRENDA
Reactome R-HSA-418594 R-HSA-380108
SignaLink P25025
BioCyc
Entrez Gene (Gene ID) 3579
BindingDB P25025

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.760 0.000 1.000 0.000 0.880 0.000 0.860 0.000 0.980 0.000 0.780 0.000 Download
Estate fingerprints 0.819 0.003 0.823 0.010 0.821 0.006 0.821 0.003 0.884 0.005 0.645 0.008 Download
MACCS fingerprints 0.807 0.005 0.907 0.005 0.857 0.005 0.851 0.003 0.920 0.000 0.718 0.006 Download
Daylight fingerprints 0.713 0.005 0.987 0.000 0.850 0.000 0.830 0.000 0.930 0.000 0.738 0.004 Download
ECFP2 fingerprints 0.913 0.005 0.971 0.004 0.942 0.004 0.942 0.004 0.990 0.000 0.892 0.004 Download
ECFP4 fingerprints 0.949 0.003 0.991 0.005 0.970 0.000 0.970 0.000 1.000 0.000 0.949 0.003 Download
ECFP6 fingerprints 0.942 0.004 0.998 0.005 0.970 0.000 0.970 0.000 1.000 0.000 0.942 0.004 Download

  Download datasets

Positive dataset Negative dataset


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School of Pharmaceutical Sciences, Central South University. All rights reserved.

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