Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.
| Uniprot primary ID | P25101 |
| PDB ID | |
| DrugBank ID | DB08932 DB00945 DB00559 DB06268 |
| BioGrid ID | 108231 |
| GuidetoPHARMACOLOGY ID | 219 |
| PharmGKB ID | PA27617 |
| KEGG ID | hsa:1909 |
| DIP ID | DIP-48718N |
| STRING ID | 9606.ENSP00000315011 |
| IntAct ID | P25101 |
| DMDM | 119606 |
| BRENDA | |
| Reactome | R-HSA-375276 R-HSA-416476 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 1909 |
| BindingDB | P25101 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.879 | 0.003 | 0.981 | 0.005 | 0.930 | 0.000 | 0.929 | 0.003 | 0.990 | 0.000 | 0.869 | 0.003 | Download |
| Estate fingerprints | 0.791 | 0.003 | 0.829 | 0.000 | 0.810 | 0.000 | 0.810 | 0.000 | 0.910 | 0.000 | 0.624 | 0.005 | Download |
| MACCS fingerprints | 0.775 | 0.005 | 0.865 | 0.005 | 0.820 | 0.000 | 0.810 | 0.000 | 0.930 | 0.000 | 0.635 | 0.005 | Download |
| Daylight fingerprints | 0.880 | 0.000 | 0.820 | 0.003 | 0.850 | 0.000 | 0.850 | 0.000 | 0.900 | 0.000 | 0.698 | 0.004 | Download |
| ECFP2 fingerprints | 0.960 | 0.000 | 0.980 | 0.003 | 0.970 | 0.000 | 0.970 | 0.000 | 0.991 | 0.003 | 0.934 | 0.005 | Download |
| ECFP4 fingerprints | 0.969 | 0.003 | 0.991 | 0.000 | 0.980 | 0.000 | 0.980 | 0.000 | 1.000 | 0.000 | 0.960 | 0.000 | Download |
| ECFP6 fingerprints | 0.950 | 0.000 | 0.990 | 0.005 | 0.970 | 0.000 | 0.970 | 0.000 | 0.998 | 0.004 | 0.950 | 0.000 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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