Target name

P25101: Endothelin-1 receptor


  Protein function

Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

  Database links

Uniprot primary ID P25101
PDB ID
DrugBank ID DB08932 DB00945 DB00559 DB06268
BioGrid ID 108231
GuidetoPHARMACOLOGY ID 219
PharmGKB ID PA27617
KEGG ID hsa:1909
DIP ID DIP-48718N
STRING ID 9606.ENSP00000315011
IntAct ID P25101
DMDM 119606
BRENDA
Reactome R-HSA-375276 R-HSA-416476
SignaLink
BioCyc
Entrez Gene (Gene ID) 1909
BindingDB P25101

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.879 0.003 0.981 0.005 0.930 0.000 0.929 0.003 0.990 0.000 0.869 0.003 Download
Estate fingerprints 0.791 0.003 0.829 0.000 0.810 0.000 0.810 0.000 0.910 0.000 0.624 0.005 Download
MACCS fingerprints 0.775 0.005 0.865 0.005 0.820 0.000 0.810 0.000 0.930 0.000 0.635 0.005 Download
Daylight fingerprints 0.880 0.000 0.820 0.003 0.850 0.000 0.850 0.000 0.900 0.000 0.698 0.004 Download
ECFP2 fingerprints 0.960 0.000 0.980 0.003 0.970 0.000 0.970 0.000 0.991 0.003 0.934 0.005 Download
ECFP4 fingerprints 0.969 0.003 0.991 0.000 0.980 0.000 0.980 0.000 1.000 0.000 0.960 0.000 Download
ECFP6 fingerprints 0.950 0.000 0.990 0.005 0.970 0.000 0.970 0.000 0.998 0.004 0.950 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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