Target name

P25103: Substance-P receptor


  Protein function

This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.

  Database links

Uniprot primary ID P25103
PDB ID 2KS9 2KSB 2KSA
DrugBank ID DB04894 DB01221 DB00673 DB09048
BioGrid ID 112732
GuidetoPHARMACOLOGY ID 360
PharmGKB ID PA36302
KEGG ID hsa:6869
DIP ID
STRING ID 9606.ENSP00000303522
IntAct ID P25103
DMDM 128359
BRENDA
Reactome R-HSA-380095 R-HSA-416476
SignaLink
BioCyc
Entrez Gene (Gene ID) 6869
BindingDB P25103

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.867 0.005 0.833 0.000 0.850 0.000 0.851 0.003 0.930 0.000 0.705 0.005 Download
Estate fingerprints 0.810 0.000 0.770 0.000 0.790 0.000 0.798 0.004 0.880 0.000 0.582 0.004 Download
MACCS fingerprints 0.849 0.003 0.743 0.005 0.796 0.005 0.806 0.005 0.890 0.000 0.594 0.005 Download
Daylight fingerprints 0.798 0.004 0.872 0.000 0.835 0.005 0.830 0.000 0.900 0.000 0.671 0.003 Download
ECFP2 fingerprints 0.948 0.004 0.932 0.004 0.940 0.000 0.940 0.000 0.980 0.000 0.883 0.005 Download
ECFP4 fingerprints 0.941 0.003 0.977 0.000 0.959 0.003 0.959 0.003 0.990 0.000 0.919 0.003 Download
ECFP6 fingerprints 0.933 0.005 0.983 0.000 0.958 0.004 0.953 0.005 0.990 0.000 0.910 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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