Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.
| Uniprot primary ID | P25105 |
| PDB ID | 2B0X |
| DrugBank ID | |
| BioGrid ID | 111696 |
| GuidetoPHARMACOLOGY ID | 334 |
| PharmGKB ID | PA33933 |
| KEGG ID | hsa:5724 |
| DIP ID | |
| STRING ID | 9606.ENSP00000301974 |
| IntAct ID | P25105 |
| DMDM | 129557 |
| BRENDA | |
| Reactome | R-HSA-373076 R-HSA-877300 R-HSA-416476 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 5724 |
| BindingDB | P25105 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.791 | 0.003 | 0.969 | 0.005 | 0.880 | 0.000 | 0.869 | 0.003 | 0.960 | 0.000 | 0.770 | 0.000 | Download |
| Estate fingerprints | 0.830 | 0.000 | 0.810 | 0.003 | 0.820 | 0.000 | 0.820 | 0.000 | 0.900 | 0.000 | 0.640 | 0.000 | Download |
| MACCS fingerprints | 0.865 | 0.005 | 0.739 | 0.003 | 0.802 | 0.004 | 0.815 | 0.005 | 0.890 | 0.000 | 0.612 | 0.004 | Download |
| Daylight fingerprints | 0.692 | 0.004 | 0.796 | 0.004 | 0.744 | 0.005 | 0.730 | 0.000 | 0.779 | 0.003 | 0.491 | 0.006 | Download |
| ECFP2 fingerprints | 0.953 | 0.005 | 0.979 | 0.000 | 0.966 | 0.005 | 0.966 | 0.005 | 0.990 | 0.000 | 0.931 | 0.003 | Download |
| ECFP4 fingerprints | 0.954 | 0.005 | 0.990 | 0.000 | 0.972 | 0.004 | 0.972 | 0.004 | 1.000 | 0.000 | 0.948 | 0.004 | Download |
| ECFP6 fingerprints | 0.920 | 0.000 | 1.000 | 0.000 | 0.960 | 0.000 | 0.958 | 0.004 | 0.990 | 0.000 | 0.919 | 0.003 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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