Target name

P25105: Platelet-activating factor receptor


  Protein function

Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system.

  Database links

Uniprot primary ID P25105
PDB ID 2B0X
DrugBank ID
BioGrid ID 111696
GuidetoPHARMACOLOGY ID 334
PharmGKB ID PA33933
KEGG ID hsa:5724
DIP ID
STRING ID 9606.ENSP00000301974
IntAct ID P25105
DMDM 129557
BRENDA
Reactome R-HSA-373076 R-HSA-877300 R-HSA-416476
SignaLink
BioCyc
Entrez Gene (Gene ID) 5724
BindingDB P25105

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.791 0.003 0.969 0.005 0.880 0.000 0.869 0.003 0.960 0.000 0.770 0.000 Download
Estate fingerprints 0.830 0.000 0.810 0.003 0.820 0.000 0.820 0.000 0.900 0.000 0.640 0.000 Download
MACCS fingerprints 0.865 0.005 0.739 0.003 0.802 0.004 0.815 0.005 0.890 0.000 0.612 0.004 Download
Daylight fingerprints 0.692 0.004 0.796 0.004 0.744 0.005 0.730 0.000 0.779 0.003 0.491 0.006 Download
ECFP2 fingerprints 0.953 0.005 0.979 0.000 0.966 0.005 0.966 0.005 0.990 0.000 0.931 0.003 Download
ECFP4 fingerprints 0.954 0.005 0.990 0.000 0.972 0.004 0.972 0.004 1.000 0.000 0.948 0.004 Download
ECFP6 fingerprints 0.920 0.000 1.000 0.000 0.960 0.000 0.958 0.004 0.990 0.000 0.919 0.003 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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