TargetNet
  Target name

P25116: Proteinase-activated receptor 1

  Protein function

High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.

  Database links
Uniprot primary ID P25116
PDB ID 3LU9 1NRO 1NRN 3HKJ 1NRR 1NRQ 1NRP 3VW7 3BEF 3HKI
DrugBank ID DB09030 DB00086
BioGrid ID 108448
GuidetoPHARMACOLOGY ID 347
PharmGKB ID PA27946
KEGG ID hsa:2149
DIP ID DIP-29703N
STRING ID 9606.ENSP00000321326
IntAct ID P25116
DMDM 20178318
BRENDA
Reactome R-HSA-140875 R-HSA-456926 R-HSA-375276 R-HSA-416476
SignaLink
BioCyc
Entrez Gene (Gene ID) 2149
BindingDB P25116
  Model Performance Metrics
Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.818 0.004 0.974 0.004 0.896 0.005 0.886 0.005 0.960 0.000 0.800 0.005 Download
Estate fingerprints 0.741 0.003 0.821 0.004 0.781 0.003 0.775 0.005 0.860 0.000 0.567 0.005 Download
MACCS fingerprints 0.799 0.003 0.837 0.005 0.818 0.004 0.816 0.005 0.900 0.000 0.636 0.005 Download
Daylight fingerprints 0.723 0.007 0.979 0.000 0.851 0.003 0.830 0.005 0.950 0.000 0.730 0.005 Download
ECFP2 fingerprints 0.850 0.000 0.972 0.000 0.911 0.003 0.910 0.000 0.980 0.000 0.832 0.004 Download
ECFP4 fingerprints 0.859 0.003 0.981 0.005 0.920 0.000 0.917 0.005 0.990 0.000 0.849 0.006 Download
ECFP6 fingerprints 0.844 0.005 0.994 0.003 0.919 0.003 0.910 0.000 0.990 0.000 0.844 0.005 Download
  Download datasets
Positive dataset Negative dataset

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 E-mail: biomed@csu.edu.cn