TargetNet
  Target name

P25774: Cathepsin S

  Protein function

Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.

  Database links
Uniprot primary ID P25774
PDB ID 1BXF 3MPE 3MPF 2H7J 2G6D 3N4C 1NQC 2HXZ 1GLO 2FQ9 2FRA 2OP3 3KWN 2C0Y 2FRQ 4P6G 4P6E 2HHN 2F1G 2HH5 1NPZ 2G7Y 2R9O 2R9N 2R9M 2FT2 3OVX 3N3G 3IEJ 1MS6 2FUD 2FYE
DrugBank ID
BioGrid ID 107900
GuidetoPHARMACOLOGY ID 2353
PharmGKB ID PA27041
KEGG ID hsa:1520
DIP ID DIP-61077N
STRING ID 9606.ENSP00000357981
IntAct ID P25774
DMDM 88984046
BRENDA 3.4.22.27
Reactome R-HSA-1679131 R-HSA-2022090 R-HSA-1474228 R-HSA-1236977 R-HSA-2132295
SignaLink
BioCyc
Entrez Gene (Gene ID) 1520
BindingDB P25774
  Model Performance Metrics
Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.689 0.006 0.937 0.000 0.813 0.005 0.787 0.005 0.930 0.000 0.646 0.005 Download
Estate fingerprints 0.744 0.005 0.836 0.005 0.790 0.000 0.780 0.000 0.870 0.000 0.578 0.004 Download
MACCS fingerprints 0.734 0.005 0.766 0.003 0.750 0.000 0.746 0.005 0.820 0.000 0.498 0.004 Download
Daylight fingerprints 0.659 0.003 0.781 0.003 0.720 0.000 0.700 0.000 0.771 0.003 0.442 0.004 Download
ECFP2 fingerprints 0.940 0.000 0.956 0.000 0.948 0.004 0.947 0.005 0.980 0.000 0.892 0.004 Download
ECFP4 fingerprints 0.920 0.000 0.980 0.003 0.950 0.000 0.950 0.000 0.990 0.000 0.901 0.003 Download
ECFP6 fingerprints 0.888 0.004 0.992 0.004 0.940 0.000 0.933 0.005 0.990 0.000 0.881 0.003 Download
  Download datasets
Positive dataset Negative dataset

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 E-mail: biomed@csu.edu.cn