Details-Calcnet-TargetNet

Target name

P25779: Cruzipain

Protein function

Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group.

Database links

Uniprot primary ID	P25779
PDB ID	1U9Q 1F29 4KLB 1ME3 1EWP 1ME4 3I06 1EWO 1EWM 1EWL 4QH6 2OZ2 4XUI 1F2A 3HD3 3IUT 1F2C 1F2B 3LXS 3KKU 2AIM 4PI3 1AIM 4W5B 4W5C
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID
DIP ID
STRING ID
IntAct ID
DMDM
BRENDA	3.4.22.51
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID)
BindingDB	P25779

Model Performance Metrics

Fingerprint type	Sensitivity	SEN_std	Specificity	SPE_std	Accuracy	ACC_std	F1-score	F1-score_std	AUC	AUC_std	MCC	MCC_std	Download model
FP2 fingerprints	0.816	0.007	0.900	0.007	0.858	0.004	0.853	0.005	0.940	0.000	0.719	0.009	Download
Estate fingerprints	0.776	0.010	0.856	0.005	0.816	0.007	0.807	0.007	0.899	0.003	0.633	0.011	Download
MACCS fingerprints	0.751	0.003	0.851	0.005	0.801	0.003	0.791	0.003	0.890	0.000	0.607	0.005	Download
Daylight fingerprints	0.725	0.007	0.817	0.003	0.771	0.003	0.757	0.007	0.825	0.005	0.541	0.011	Download
ECFP2 fingerprints	0.940	0.005	0.958	0.005	0.949	0.003	0.949	0.003	0.980	0.000	0.896	0.008	Download
ECFP4 fingerprints	0.926	0.005	0.950	0.004	0.938	0.004	0.938	0.004	0.980	0.000	0.878	0.006	Download
ECFP6 fingerprints	0.904	0.010	0.982	0.005	0.943	0.007	0.939	0.003	0.979	0.003	0.885	0.012	Download

Download datasets

Positive dataset

Negative dataset