Target name

P25779: Cruzipain


  Protein function

Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group.

  Database links

Uniprot primary ID P25779
PDB ID 1U9Q 1F29 4KLB 1ME3 1EWP 1ME4 3I06 1EWO 1EWM 1EWL 4QH6 2OZ2 4XUI 1F2A 3HD3 3IUT 1F2C 1F2B 3LXS 3KKU 2AIM 4PI3 1AIM 4W5B 4W5C
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID
DIP ID
STRING ID
IntAct ID
DMDM
BRENDA 3.4.22.51
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID)
BindingDB P25779

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.816 0.007 0.900 0.007 0.858 0.004 0.853 0.005 0.940 0.000 0.719 0.009 Download
Estate fingerprints 0.776 0.010 0.856 0.005 0.816 0.007 0.807 0.007 0.899 0.003 0.633 0.011 Download
MACCS fingerprints 0.751 0.003 0.851 0.005 0.801 0.003 0.791 0.003 0.890 0.000 0.607 0.005 Download
Daylight fingerprints 0.725 0.007 0.817 0.003 0.771 0.003 0.757 0.007 0.825 0.005 0.541 0.011 Download
ECFP2 fingerprints 0.940 0.005 0.958 0.005 0.949 0.003 0.949 0.003 0.980 0.000 0.896 0.008 Download
ECFP4 fingerprints 0.926 0.005 0.950 0.004 0.938 0.004 0.938 0.004 0.980 0.000 0.878 0.006 Download
ECFP6 fingerprints 0.904 0.010 0.982 0.005 0.943 0.007 0.939 0.003 0.979 0.003 0.885 0.012 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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