Target name

P25929: Neuropeptide Y receptor type 1


  Protein function

Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid.

  Database links

Uniprot primary ID P25929
PDB ID 2F1U 2IIL
DrugBank ID
BioGrid ID 110946
GuidetoPHARMACOLOGY ID 305
PharmGKB ID PA258
KEGG ID hsa:4886
DIP ID
STRING ID 9606.ENSP00000354652
IntAct ID P25929
DMDM 128997
BRENDA
Reactome R-HSA-418594 R-HSA-375276
SignaLink
BioCyc
Entrez Gene (Gene ID) 4886
BindingDB P25929

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.726 0.005 0.894 0.003 0.810 0.000 0.791 0.003 0.850 0.000 0.628 0.004 Download
Estate fingerprints 0.723 0.005 0.717 0.005 0.720 0.000 0.720 0.000 0.790 0.000 0.439 0.007 Download
MACCS fingerprints 0.774 0.005 0.736 0.005 0.755 0.005 0.760 0.000 0.817 0.005 0.508 0.006 Download
Daylight fingerprints 0.752 0.004 0.774 0.005 0.763 0.005 0.761 0.003 0.800 0.000 0.529 0.006 Download
ECFP2 fingerprints 0.767 0.005 0.913 0.003 0.840 0.000 0.829 0.003 0.897 0.005 0.690 0.005 Download
ECFP4 fingerprints 0.764 0.005 0.956 0.000 0.860 0.000 0.847 0.005 0.919 0.003 0.736 0.005 Download
ECFP6 fingerprints 0.751 0.003 0.969 0.004 0.860 0.000 0.845 0.005 0.901 0.003 0.742 0.004 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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