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E-mail: biomed@csu.edu.cn
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Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.
| Uniprot primary ID | P26358 |
| PDB ID | 3PTA 3EPZ 4WXX 3SWR 4YOC |
| DrugBank ID | DB01262 DB01099 DB00928 DB01035 |
| BioGrid ID | 108123 |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | PA27443 |
| KEGG ID | hsa:1786 |
| DIP ID | DIP-39693N |
| STRING ID | 9606.ENSP00000352516 |
| IntAct ID | P26358 |
| DMDM | 12231019 |
| BRENDA | 2.1.1.37 |
| Reactome | R-HSA-427413 R-HSA-5334118 R-HSA-212300 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 1786 |
| BindingDB | P26358 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.693 | 0.013 | 0.861 | 0.007 | 0.777 | 0.007 | 0.755 | 0.010 | 0.854 | 0.005 | 0.561 | 0.017 | Download |
| Estate fingerprints | 0.730 | 0.012 | 0.756 | 0.011 | 0.743 | 0.012 | 0.741 | 0.011 | 0.816 | 0.005 | 0.487 | 0.019 | Download |
| MACCS fingerprints | 0.727 | 0.016 | 0.749 | 0.014 | 0.738 | 0.010 | 0.735 | 0.011 | 0.805 | 0.005 | 0.478 | 0.015 | Download |
| Daylight fingerprints | 0.627 | 0.008 | 0.705 | 0.011 | 0.666 | 0.007 | 0.652 | 0.008 | 0.714 | 0.010 | 0.330 | 0.011 | Download |
| ECFP2 fingerprints | 0.820 | 0.011 | 0.848 | 0.018 | 0.834 | 0.012 | 0.832 | 0.009 | 0.907 | 0.005 | 0.668 | 0.021 | Download |
| ECFP4 fingerprints | 0.801 | 0.017 | 0.887 | 0.008 | 0.844 | 0.010 | 0.836 | 0.013 | 0.906 | 0.005 | 0.689 | 0.019 | Download |
| ECFP6 fingerprints | 0.789 | 0.010 | 0.883 | 0.009 | 0.836 | 0.010 | 0.828 | 0.008 | 0.893 | 0.005 | 0.674 | 0.015 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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