Target name

P26358: DNA (cytosine-5)-methyltransferase 1


  Protein function

Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.

  Database links

Uniprot primary ID P26358
PDB ID 3PTA 3EPZ 4WXX 3SWR 4YOC
DrugBank ID DB01262 DB01099 DB00928 DB01035
BioGrid ID 108123
GuidetoPHARMACOLOGY ID
PharmGKB ID PA27443
KEGG ID hsa:1786
DIP ID DIP-39693N
STRING ID 9606.ENSP00000352516
IntAct ID P26358
DMDM 12231019
BRENDA 2.1.1.37
Reactome R-HSA-427413 R-HSA-5334118 R-HSA-212300
SignaLink
BioCyc
Entrez Gene (Gene ID) 1786
BindingDB P26358

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.693 0.013 0.861 0.007 0.777 0.007 0.755 0.010 0.854 0.005 0.561 0.017 Download
Estate fingerprints 0.730 0.012 0.756 0.011 0.743 0.012 0.741 0.011 0.816 0.005 0.487 0.019 Download
MACCS fingerprints 0.727 0.016 0.749 0.014 0.738 0.010 0.735 0.011 0.805 0.005 0.478 0.015 Download
Daylight fingerprints 0.627 0.008 0.705 0.011 0.666 0.007 0.652 0.008 0.714 0.010 0.330 0.011 Download
ECFP2 fingerprints 0.820 0.011 0.848 0.018 0.834 0.012 0.832 0.009 0.907 0.005 0.668 0.021 Download
ECFP4 fingerprints 0.801 0.017 0.887 0.008 0.844 0.010 0.836 0.013 0.906 0.005 0.689 0.019 Download
ECFP6 fingerprints 0.789 0.010 0.883 0.009 0.836 0.010 0.828 0.008 0.893 0.005 0.674 0.015 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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