Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.
| Uniprot primary ID | P26684 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | |
| GuidetoPHARMACOLOGY ID | 219 |
| PharmGKB ID | |
| KEGG ID | rno:24326 |
| DIP ID | |
| STRING ID | 10116.ENSRNOP00000054967 |
| IntAct ID | |
| DMDM | |
| BRENDA | |
| Reactome | R-RNO-375276 R-RNO-416476 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 24326 |
| BindingDB | P26684 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.900 | 0.005 | 0.980 | 0.004 | 0.940 | 0.000 | 0.934 | 0.005 | 0.990 | 0.000 | 0.878 | 0.006 | Download |
| Estate fingerprints | 0.898 | 0.004 | 0.788 | 0.003 | 0.843 | 0.005 | 0.851 | 0.003 | 0.910 | 0.000 | 0.692 | 0.004 | Download |
| MACCS fingerprints | 0.910 | 0.000 | 0.870 | 0.005 | 0.890 | 0.000 | 0.890 | 0.000 | 0.960 | 0.000 | 0.780 | 0.000 | Download |
| Daylight fingerprints | 0.919 | 0.003 | 0.877 | 0.005 | 0.898 | 0.004 | 0.900 | 0.000 | 0.933 | 0.005 | 0.796 | 0.005 | Download |
| ECFP2 fingerprints | 0.990 | 0.000 | 0.970 | 0.000 | 0.980 | 0.000 | 0.980 | 0.000 | 1.000 | 0.000 | 0.958 | 0.004 | Download |
| ECFP4 fingerprints | 0.980 | 0.000 | 0.990 | 0.000 | 0.985 | 0.005 | 0.985 | 0.005 | 1.000 | 0.000 | 0.969 | 0.003 | Download |
| ECFP6 fingerprints | 0.954 | 0.005 | 0.990 | 0.005 | 0.972 | 0.004 | 0.972 | 0.004 | 1.000 | 0.000 | 0.950 | 0.000 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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