Target name

P26684: Endothelin-1 receptor


  Protein function

Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.

  Database links

Uniprot primary ID P26684
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 219
PharmGKB ID
KEGG ID rno:24326
DIP ID
STRING ID 10116.ENSRNOP00000054967
IntAct ID
DMDM
BRENDA
Reactome R-RNO-375276 R-RNO-416476
SignaLink
BioCyc
Entrez Gene (Gene ID) 24326
BindingDB P26684

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.900 0.005 0.980 0.004 0.940 0.000 0.934 0.005 0.990 0.000 0.878 0.006 Download
Estate fingerprints 0.898 0.004 0.788 0.003 0.843 0.005 0.851 0.003 0.910 0.000 0.692 0.004 Download
MACCS fingerprints 0.910 0.000 0.870 0.005 0.890 0.000 0.890 0.000 0.960 0.000 0.780 0.000 Download
Daylight fingerprints 0.919 0.003 0.877 0.005 0.898 0.004 0.900 0.000 0.933 0.005 0.796 0.005 Download
ECFP2 fingerprints 0.990 0.000 0.970 0.000 0.980 0.000 0.980 0.000 1.000 0.000 0.958 0.004 Download
ECFP4 fingerprints 0.980 0.000 0.990 0.000 0.985 0.005 0.985 0.005 1.000 0.000 0.969 0.003 Download
ECFP6 fingerprints 0.954 0.005 0.990 0.005 0.972 0.004 0.972 0.004 1.000 0.000 0.950 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn