Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
| Uniprot primary ID | P27815 |
| PDB ID | 3I8V 2QYK 3TVX |
| DrugBank ID | DB01088 DB00651 DB00920 DB00975 DB08811 DB05266 DB01656 |
| BioGrid ID | 111167 |
| GuidetoPHARMACOLOGY ID | 1300 |
| PharmGKB ID | PA33128 |
| KEGG ID | hsa:5141 |
| DIP ID | |
| STRING ID | 9606.ENSP00000270474 |
| IntAct ID | P27815 |
| DMDM | 116242706 |
| BRENDA | 3.1.4.17 3.1.4.53 |
| Reactome | R-HSA-180024 R-HSA-418555 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 5141 |
| BindingDB | P27815 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.884 | 0.005 | 0.954 | 0.003 | 0.919 | 0.003 | 0.914 | 0.005 | 0.970 | 0.000 | 0.835 | 0.005 | Download |
| Estate fingerprints | 0.663 | 0.005 | 0.705 | 0.000 | 0.684 | 0.005 | 0.674 | 0.005 | 0.780 | 0.000 | 0.370 | 0.007 | Download |
| MACCS fingerprints | 0.787 | 0.005 | 0.797 | 0.005 | 0.792 | 0.004 | 0.790 | 0.000 | 0.872 | 0.004 | 0.586 | 0.008 | Download |
| Daylight fingerprints | 0.878 | 0.004 | 0.860 | 0.003 | 0.869 | 0.003 | 0.869 | 0.003 | 0.911 | 0.003 | 0.738 | 0.004 | Download |
| ECFP2 fingerprints | 0.939 | 0.006 | 0.937 | 0.004 | 0.938 | 0.004 | 0.938 | 0.004 | 0.990 | 0.000 | 0.871 | 0.006 | Download |
| ECFP4 fingerprints | 0.940 | 0.000 | 0.980 | 0.000 | 0.960 | 0.000 | 0.960 | 0.000 | 0.990 | 0.000 | 0.924 | 0.005 | Download |
| ECFP6 fingerprints | 0.921 | 0.003 | 0.999 | 0.005 | 0.960 | 0.000 | 0.954 | 0.005 | 0.990 | 0.000 | 0.914 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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