Target name

P27815: cAMP-specific 3',5'-cyclic phosphodiesterase 4A


  Protein function

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.

  Database links

Uniprot primary ID P27815
PDB ID 3I8V 2QYK 3TVX
DrugBank ID DB01088 DB00651 DB00920 DB00975 DB08811 DB05266 DB01656
BioGrid ID 111167
GuidetoPHARMACOLOGY ID 1300
PharmGKB ID PA33128
KEGG ID hsa:5141
DIP ID
STRING ID 9606.ENSP00000270474
IntAct ID P27815
DMDM 116242706
BRENDA 3.1.4.17 3.1.4.53
Reactome R-HSA-180024 R-HSA-418555
SignaLink
BioCyc
Entrez Gene (Gene ID) 5141
BindingDB P27815

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.884 0.005 0.954 0.003 0.919 0.003 0.914 0.005 0.970 0.000 0.835 0.005 Download
Estate fingerprints 0.663 0.005 0.705 0.000 0.684 0.005 0.674 0.005 0.780 0.000 0.370 0.007 Download
MACCS fingerprints 0.787 0.005 0.797 0.005 0.792 0.004 0.790 0.000 0.872 0.004 0.586 0.008 Download
Daylight fingerprints 0.878 0.004 0.860 0.003 0.869 0.003 0.869 0.003 0.911 0.003 0.738 0.004 Download
ECFP2 fingerprints 0.939 0.006 0.937 0.004 0.938 0.004 0.938 0.004 0.990 0.000 0.871 0.006 Download
ECFP4 fingerprints 0.940 0.000 0.980 0.000 0.960 0.000 0.960 0.000 0.990 0.000 0.924 0.005 Download
ECFP6 fingerprints 0.921 0.003 0.999 0.005 0.960 0.000 0.954 0.005 0.990 0.000 0.914 0.005 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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