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E-mail: biomed@csu.edu.cn
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G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction.
| Uniprot primary ID | P28221 |
| PDB ID | |
| DrugBank ID | DB00953 DB00952 DB01049 DB00320 DB00321 DB00734 DB00918 |
| BioGrid ID | 109584 |
| GuidetoPHARMACOLOGY ID | 3 |
| PharmGKB ID | PA29550 |
| KEGG ID | hsa:3352 |
| DIP ID | |
| STRING ID | 9606.ENSP00000313661 |
| IntAct ID | |
| DMDM | 112819 |
| BRENDA | |
| Reactome | R-HSA-418594 R-HSA-390666 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 3352 |
| BindingDB | P28221 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.802 | 0.004 | 0.894 | 0.000 | 0.848 | 0.004 | 0.839 | 0.003 | 0.930 | 0.000 | 0.695 | 0.005 | Download |
| Estate fingerprints | 0.775 | 0.005 | 0.819 | 0.004 | 0.797 | 0.005 | 0.790 | 0.000 | 0.866 | 0.005 | 0.591 | 0.003 | Download |
| MACCS fingerprints | 0.830 | 0.000 | 0.770 | 0.005 | 0.800 | 0.000 | 0.800 | 0.000 | 0.880 | 0.000 | 0.596 | 0.005 | Download |
| Daylight fingerprints | 0.739 | 0.003 | 0.921 | 0.000 | 0.830 | 0.000 | 0.816 | 0.005 | 0.890 | 0.000 | 0.676 | 0.007 | Download |
| ECFP2 fingerprints | 0.900 | 0.000 | 0.924 | 0.005 | 0.912 | 0.004 | 0.911 | 0.003 | 0.970 | 0.000 | 0.828 | 0.004 | Download |
| ECFP4 fingerprints | 0.870 | 0.005 | 0.970 | 0.000 | 0.920 | 0.000 | 0.917 | 0.005 | 0.980 | 0.000 | 0.847 | 0.005 | Download |
| ECFP6 fingerprints | 0.802 | 0.004 | 0.996 | 0.000 | 0.899 | 0.003 | 0.889 | 0.003 | 0.980 | 0.000 | 0.809 | 0.003 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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