Target name

P28221: 5-hydroxytryptamine receptor 1D


  Protein function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction.

  Database links

Uniprot primary ID P28221
PDB ID
DrugBank ID DB00953 DB00952 DB01049 DB00320 DB00321 DB00734 DB00918
BioGrid ID 109584
GuidetoPHARMACOLOGY ID 3
PharmGKB ID PA29550
KEGG ID hsa:3352
DIP ID
STRING ID 9606.ENSP00000313661
IntAct ID
DMDM 112819
BRENDA
Reactome R-HSA-418594 R-HSA-390666
SignaLink
BioCyc
Entrez Gene (Gene ID) 3352
BindingDB P28221

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.802 0.004 0.894 0.000 0.848 0.004 0.839 0.003 0.930 0.000 0.695 0.005 Download
Estate fingerprints 0.775 0.005 0.819 0.004 0.797 0.005 0.790 0.000 0.866 0.005 0.591 0.003 Download
MACCS fingerprints 0.830 0.000 0.770 0.005 0.800 0.000 0.800 0.000 0.880 0.000 0.596 0.005 Download
Daylight fingerprints 0.739 0.003 0.921 0.000 0.830 0.000 0.816 0.005 0.890 0.000 0.676 0.007 Download
ECFP2 fingerprints 0.900 0.000 0.924 0.005 0.912 0.004 0.911 0.003 0.970 0.000 0.828 0.004 Download
ECFP4 fingerprints 0.870 0.005 0.970 0.000 0.920 0.000 0.917 0.005 0.980 0.000 0.847 0.005 Download
ECFP6 fingerprints 0.802 0.004 0.996 0.000 0.899 0.003 0.889 0.003 0.980 0.000 0.809 0.003 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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