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E-mail: biomed@csu.edu.cn
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G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.
| Uniprot primary ID | P28222 |
| PDB ID | 2G1X 4IAR 4IAQ |
| DrugBank ID | DB00953 DB00952 DB01049 DB08807 DB00320 DB00321 DB00246 |
| BioGrid ID | 109583 |
| GuidetoPHARMACOLOGY ID | 2 |
| PharmGKB ID | PA29549 |
| KEGG ID | hsa:3351 |
| DIP ID | |
| STRING ID | 9606.ENSP00000358963 |
| IntAct ID | P28222 |
| DMDM | 112821 |
| BRENDA | |
| Reactome | R-HSA-418594 R-HSA-390666 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 3351 |
| BindingDB | P28222 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.801 | 0.003 | 0.899 | 0.003 | 0.850 | 0.000 | 0.841 | 0.003 | 0.922 | 0.004 | 0.702 | 0.004 | Download |
| Estate fingerprints | 0.805 | 0.005 | 0.795 | 0.000 | 0.800 | 0.000 | 0.800 | 0.000 | 0.880 | 0.000 | 0.599 | 0.003 | Download |
| MACCS fingerprints | 0.832 | 0.004 | 0.750 | 0.003 | 0.791 | 0.003 | 0.800 | 0.000 | 0.880 | 0.000 | 0.586 | 0.005 | Download |
| Daylight fingerprints | 0.670 | 0.000 | 0.930 | 0.004 | 0.800 | 0.000 | 0.770 | 0.000 | 0.880 | 0.000 | 0.624 | 0.005 | Download |
| ECFP2 fingerprints | 0.893 | 0.005 | 0.903 | 0.003 | 0.898 | 0.004 | 0.898 | 0.004 | 0.963 | 0.005 | 0.795 | 0.005 | Download |
| ECFP4 fingerprints | 0.874 | 0.005 | 0.956 | 0.000 | 0.915 | 0.005 | 0.910 | 0.000 | 0.970 | 0.000 | 0.832 | 0.004 | Download |
| ECFP6 fingerprints | 0.817 | 0.005 | 0.981 | 0.000 | 0.899 | 0.003 | 0.891 | 0.003 | 0.970 | 0.000 | 0.808 | 0.006 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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