Target name

P28222: 5-hydroxytryptamine receptor 1B


  Protein function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.

  Database links

Uniprot primary ID P28222
PDB ID 2G1X 4IAR 4IAQ
DrugBank ID DB00953 DB00952 DB01049 DB08807 DB00320 DB00321 DB00246
BioGrid ID 109583
GuidetoPHARMACOLOGY ID 2
PharmGKB ID PA29549
KEGG ID hsa:3351
DIP ID
STRING ID 9606.ENSP00000358963
IntAct ID P28222
DMDM 112821
BRENDA
Reactome R-HSA-418594 R-HSA-390666
SignaLink
BioCyc
Entrez Gene (Gene ID) 3351
BindingDB P28222

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.801 0.003 0.899 0.003 0.850 0.000 0.841 0.003 0.922 0.004 0.702 0.004 Download
Estate fingerprints 0.805 0.005 0.795 0.000 0.800 0.000 0.800 0.000 0.880 0.000 0.599 0.003 Download
MACCS fingerprints 0.832 0.004 0.750 0.003 0.791 0.003 0.800 0.000 0.880 0.000 0.586 0.005 Download
Daylight fingerprints 0.670 0.000 0.930 0.004 0.800 0.000 0.770 0.000 0.880 0.000 0.624 0.005 Download
ECFP2 fingerprints 0.893 0.005 0.903 0.003 0.898 0.004 0.898 0.004 0.963 0.005 0.795 0.005 Download
ECFP4 fingerprints 0.874 0.005 0.956 0.000 0.915 0.005 0.910 0.000 0.970 0.000 0.832 0.004 Download
ECFP6 fingerprints 0.817 0.005 0.981 0.000 0.899 0.003 0.891 0.003 0.970 0.000 0.808 0.006 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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