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E-mail: biomed@csu.edu.cn
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G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.
| Uniprot primary ID | P28564 |
| PDB ID | |
| DrugBank ID | |
| BioGrid ID | |
| GuidetoPHARMACOLOGY ID | 2 |
| PharmGKB ID | |
| KEGG ID | rno:25075 |
| DIP ID | |
| STRING ID | 10116.ENSRNOP00000017411 |
| IntAct ID | |
| DMDM | |
| BRENDA | |
| Reactome | R-RNO-418594 R-RNO-390666 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 25075 |
| BindingDB | P28564 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.832 | 0.008 | 0.792 | 0.011 | 0.812 | 0.008 | 0.817 | 0.007 | 0.900 | 0.000 | 0.623 | 0.013 | Download |
| Estate fingerprints | 0.822 | 0.011 | 0.742 | 0.011 | 0.782 | 0.008 | 0.791 | 0.007 | 0.848 | 0.004 | 0.567 | 0.014 | Download |
| MACCS fingerprints | 0.836 | 0.008 | 0.694 | 0.006 | 0.765 | 0.005 | 0.782 | 0.006 | 0.850 | 0.000 | 0.537 | 0.011 | Download |
| Daylight fingerprints | 0.764 | 0.008 | 0.746 | 0.007 | 0.755 | 0.005 | 0.758 | 0.006 | 0.783 | 0.005 | 0.512 | 0.008 | Download |
| ECFP2 fingerprints | 0.944 | 0.007 | 0.800 | 0.008 | 0.872 | 0.004 | 0.881 | 0.006 | 0.944 | 0.005 | 0.754 | 0.012 | Download |
| ECFP4 fingerprints | 0.928 | 0.006 | 0.872 | 0.005 | 0.900 | 0.000 | 0.901 | 0.003 | 0.960 | 0.000 | 0.798 | 0.006 | Download |
| ECFP6 fingerprints | 0.886 | 0.005 | 0.898 | 0.005 | 0.892 | 0.004 | 0.892 | 0.004 | 0.960 | 0.000 | 0.785 | 0.007 | Download |
| Positive dataset | Negative dataset |
The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
E-mail: biomed@csu.edu.cn
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