Target name

P28564: 5-hydroxytryptamine receptor 1B


  Protein function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.

  Database links

Uniprot primary ID P28564
PDB ID
DrugBank ID
BioGrid ID
GuidetoPHARMACOLOGY ID 2
PharmGKB ID
KEGG ID rno:25075
DIP ID
STRING ID 10116.ENSRNOP00000017411
IntAct ID
DMDM
BRENDA
Reactome R-RNO-418594 R-RNO-390666
SignaLink
BioCyc
Entrez Gene (Gene ID) 25075
BindingDB P28564

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.832 0.008 0.792 0.011 0.812 0.008 0.817 0.007 0.900 0.000 0.623 0.013 Download
Estate fingerprints 0.822 0.011 0.742 0.011 0.782 0.008 0.791 0.007 0.848 0.004 0.567 0.014 Download
MACCS fingerprints 0.836 0.008 0.694 0.006 0.765 0.005 0.782 0.006 0.850 0.000 0.537 0.011 Download
Daylight fingerprints 0.764 0.008 0.746 0.007 0.755 0.005 0.758 0.006 0.783 0.005 0.512 0.008 Download
ECFP2 fingerprints 0.944 0.007 0.800 0.008 0.872 0.004 0.881 0.006 0.944 0.005 0.754 0.012 Download
ECFP4 fingerprints 0.928 0.006 0.872 0.005 0.900 0.000 0.901 0.003 0.960 0.000 0.798 0.006 Download
ECFP6 fingerprints 0.886 0.005 0.898 0.005 0.892 0.004 0.892 0.004 0.960 0.000 0.785 0.007 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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