TargetNet
  Target name

P28566: 5-hydroxytryptamine receptor 1E

  Protein function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.

  Database links
Uniprot primary ID P28566
PDB ID
DrugBank ID DB01221 DB01238 DB01049 DB00216 DB00334 DB01224 DB00408
BioGrid ID 109586
GuidetoPHARMACOLOGY ID 4
PharmGKB ID PA29552
KEGG ID hsa:3354
DIP ID
STRING ID 9606.ENSP00000307766
IntAct ID P28566
DMDM 112822
BRENDA
Reactome R-HSA-418594 R-HSA-390666
SignaLink
BioCyc
Entrez Gene (Gene ID) 3354
BindingDB P28566
  Model Performance Metrics
Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.717 0.027 0.655 0.016 0.686 0.020 0.695 0.021 0.767 0.012 0.371 0.035 Download
Estate fingerprints 0.649 0.014 0.597 0.016 0.623 0.013 0.631 0.014 0.704 0.010 0.243 0.028 Download
MACCS fingerprints 0.667 0.017 0.681 0.021 0.674 0.013 0.673 0.014 0.715 0.008 0.351 0.026 Download
Daylight fingerprints 0.606 0.013 0.714 0.016 0.660 0.011 0.641 0.014 0.710 0.007 0.321 0.023 Download
ECFP2 fingerprints 0.828 0.013 0.684 0.014 0.756 0.013 0.771 0.012 0.832 0.006 0.518 0.025 Download
ECFP4 fingerprints 0.810 0.014 0.660 0.017 0.735 0.011 0.754 0.011 0.845 0.007 0.473 0.023 Download
ECFP6 fingerprints 0.784 0.016 0.638 0.018 0.711 0.013 0.731 0.011 0.815 0.007 0.427 0.023 Download
  Download datasets
Positive dataset Negative dataset

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 E-mail: biomed@csu.edu.cn