Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Specifically binds 9-cis retinoic acid (9C-RA).
| Uniprot primary ID | P28702 |
| PDB ID | 1H9U 1UHL |
| DrugBank ID | DB00459 DB00799 DB00523 DB00210 DB00307 DB00755 |
| BioGrid ID | 112169 |
| GuidetoPHARMACOLOGY ID | 611 |
| PharmGKB ID | PA34891 |
| KEGG ID | hsa:6257 |
| DIP ID | |
| STRING ID | 9606.ENSP00000363812 |
| IntAct ID | P28702 |
| DMDM | 1350911 |
| BRENDA | |
| Reactome | R-HSA-383280 R-HSA-5362517 |
| SignaLink | P28702 |
| BioCyc | |
| Entrez Gene (Gene ID) | 6257 |
| BindingDB | P28702 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.959 | 0.003 | 0.959 | 0.000 | 0.959 | 0.003 | 0.959 | 0.003 | 0.997 | 0.005 | 0.910 | 0.005 | Download |
| Estate fingerprints | 0.970 | 0.007 | 0.948 | 0.003 | 0.959 | 0.003 | 0.961 | 0.006 | 0.990 | 0.000 | 0.918 | 0.011 | Download |
| MACCS fingerprints | 0.941 | 0.003 | 0.979 | 0.000 | 0.960 | 0.000 | 0.960 | 0.000 | 1.000 | 0.000 | 0.921 | 0.003 | Download |
| Daylight fingerprints | 0.875 | 0.008 | 0.979 | 0.003 | 0.927 | 0.005 | 0.927 | 0.005 | 0.988 | 0.004 | 0.860 | 0.007 | Download |
| ECFP2 fingerprints | 1.000 | 0.000 | 1.000 | 0.000 | 1.000 | 0.000 | 1.000 | 0.000 | 1.000 | 0.000 | 1.000 | 0.000 | Download |
| ECFP4 fingerprints | 1.000 | 0.000 | 1.000 | 0.000 | 1.000 | 0.000 | 1.000 | 0.000 | 1.000 | 0.000 | 1.000 | 0.000 | Download |
| ECFP6 fingerprints | 1.000 | 0.000 | 1.000 | 0.000 | 1.000 | 0.000 | 1.000 | 0.000 | 1.000 | 0.000 | 1.000 | 0.000 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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