Target name

P28702: Retinoic acid receptor RXR-beta


  Protein function

Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (By similarity). Specifically binds 9-cis retinoic acid (9C-RA).

  Database links

Uniprot primary ID P28702
PDB ID 1H9U 1UHL
DrugBank ID DB00459 DB00799 DB00523 DB00210 DB00307 DB00755
BioGrid ID 112169
GuidetoPHARMACOLOGY ID 611
PharmGKB ID PA34891
KEGG ID hsa:6257
DIP ID
STRING ID 9606.ENSP00000363812
IntAct ID P28702
DMDM 1350911
BRENDA
Reactome R-HSA-383280 R-HSA-5362517
SignaLink P28702
BioCyc
Entrez Gene (Gene ID) 6257
BindingDB P28702

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.959 0.003 0.959 0.000 0.959 0.003 0.959 0.003 0.997 0.005 0.910 0.005 Download
Estate fingerprints 0.970 0.007 0.948 0.003 0.959 0.003 0.961 0.006 0.990 0.000 0.918 0.011 Download
MACCS fingerprints 0.941 0.003 0.979 0.000 0.960 0.000 0.960 0.000 1.000 0.000 0.921 0.003 Download
Daylight fingerprints 0.875 0.008 0.979 0.003 0.927 0.005 0.927 0.005 0.988 0.004 0.860 0.007 Download
ECFP2 fingerprints 1.000 0.000 1.000 0.000 1.000 0.000 1.000 0.000 1.000 0.000 1.000 0.000 Download
ECFP4 fingerprints 1.000 0.000 1.000 0.000 1.000 0.000 1.000 0.000 1.000 0.000 1.000 0.000 Download
ECFP6 fingerprints 1.000 0.000 1.000 0.000 1.000 0.000 1.000 0.000 1.000 0.000 1.000 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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