TargetNet
  Target name

P28845: Corticosteroid 11-beta-dehydrogenase isozyme 1

  Protein function

Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).

  Database links
Uniprot primary ID P28845
PDB ID 3BYZ 3BZU 4K1L 3HFG 3CH6 1XU9 2BEL 3D4N 3D3E 1XU7 3D5Q 4BB5 4BB6 2IRW 3H6K 4IJW 3OQ1 4IJV 4IJU 3QQP 3FCO 2ILT 3EY4 4HX5 3FRJ 3CZR 2RBE 4C7J 4C7K 3PDJ 3TFQ 4HFR 4P38
DrugBank ID DB00635
BioGrid ID 109523
GuidetoPHARMACOLOGY ID 2763
PharmGKB ID PA29476
KEGG ID hsa:3290
DIP ID DIP-59618N
STRING ID 9606.ENSP00000261465
IntAct ID P28845
DMDM 118569
BRENDA 1.1.1.146 1.1.1.B40
Reactome R-HSA-194002
SignaLink
BioCyc MetaCyc:HS04154-MONOMER
Entrez Gene (Gene ID) 3290
BindingDB P28845
  Model Performance Metrics
Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.824 0.005 0.816 0.003 0.820 0.000 0.820 0.000 0.910 0.000 0.640 0.000 Download
Estate fingerprints 0.782 0.004 0.740 0.004 0.761 0.003 0.770 0.000 0.840 0.000 0.526 0.005 Download
MACCS fingerprints 0.756 0.005 0.784 0.005 0.770 0.000 0.768 0.004 0.850 0.000 0.540 0.007 Download
Daylight fingerprints 0.800 0.000 0.758 0.000 0.779 0.003 0.780 0.000 0.830 0.000 0.551 0.003 Download
ECFP2 fingerprints 0.932 0.004 0.928 0.000 0.930 0.000 0.930 0.000 0.980 0.000 0.857 0.005 Download
ECFP4 fingerprints 0.939 0.003 0.961 0.000 0.950 0.000 0.950 0.000 0.980 0.000 0.900 0.000 Download
ECFP6 fingerprints 0.912 0.004 0.968 0.003 0.940 0.000 0.940 0.000 0.980 0.000 0.881 0.003 Download
  Download datasets
Positive dataset Negative dataset

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 E-mail: biomed@csu.edu.cn