Target name

P29274: Adenosine receptor A2a


  Protein function

Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

  Database links

Uniprot primary ID P29274
PDB ID 4UG2 3EML 3QAK 1UPE 3PWH 1MMH 3VGA 4UHR 2YDO 3REY 3VG9 2YDV 4EIY 3RFM 3UZC 3UZA
DrugBank ID DB00651 DB00640 DB06213 DB01412 DB00201 DB00824 DB00806
BioGrid ID 106647
GuidetoPHARMACOLOGY ID 19
PharmGKB ID PA24584
KEGG ID hsa:135
DIP ID
STRING ID 9606.ENSP00000336630
IntAct ID P29274
DMDM 543740
BRENDA
Reactome R-HSA-187024 R-HSA-418555 R-HSA-417973
SignaLink
BioCyc
Entrez Gene (Gene ID) 135
BindingDB P29274

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.877 0.005 0.903 0.005 0.890 0.000 0.890 0.000 0.950 0.000 0.780 0.000 Download
Estate fingerprints 0.838 0.004 0.762 0.000 0.800 0.000 0.810 0.000 0.890 0.000 0.609 0.003 Download
MACCS fingerprints 0.901 0.003 0.799 0.000 0.850 0.000 0.860 0.000 0.930 0.000 0.709 0.003 Download
Daylight fingerprints 0.780 0.000 0.820 0.000 0.800 0.000 0.800 0.000 0.850 0.000 0.610 0.000 Download
ECFP2 fingerprints 0.940 0.000 0.900 0.005 0.920 0.000 0.923 0.005 0.980 0.000 0.849 0.003 Download
ECFP4 fingerprints 0.904 0.005 0.976 0.000 0.940 0.000 0.939 0.003 0.980 0.000 0.879 0.003 Download
ECFP6 fingerprints 0.866 0.005 0.974 0.000 0.920 0.000 0.920 0.000 0.980 0.000 0.850 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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