Target name

P29371: Neuromedin-K receptor


  Protein function

This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P.

  Database links

Uniprot primary ID P29371
PDB ID
DrugBank ID
BioGrid ID 112733
GuidetoPHARMACOLOGY ID 362
PharmGKB ID PA36304
KEGG ID hsa:6870
DIP ID
STRING ID 9606.ENSP00000303325
IntAct ID P29371
DMDM 128364
BRENDA
Reactome R-HSA-380095 R-HSA-416476
SignaLink
BioCyc
Entrez Gene (Gene ID) 6870
BindingDB P29371

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.945 0.005 0.895 0.005 0.920 0.000 0.922 0.004 0.970 0.000 0.844 0.005 Download
Estate fingerprints 0.909 0.006 0.745 0.003 0.827 0.005 0.840 0.000 0.900 0.000 0.663 0.008 Download
MACCS fingerprints 0.916 0.005 0.788 0.004 0.852 0.004 0.861 0.003 0.920 0.000 0.711 0.006 Download
Daylight fingerprints 0.788 0.006 0.914 0.000 0.851 0.003 0.841 0.003 0.920 0.000 0.709 0.006 Download
ECFP2 fingerprints 0.950 0.000 0.910 0.000 0.930 0.000 0.932 0.004 0.980 0.000 0.865 0.005 Download
ECFP4 fingerprints 0.963 0.005 0.957 0.005 0.960 0.000 0.960 0.000 0.990 0.000 0.923 0.005 Download
ECFP6 fingerprints 0.936 0.005 0.982 0.004 0.959 0.003 0.958 0.004 0.990 0.000 0.915 0.007 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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