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E-mail: biomed@csu.edu.cn
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Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.
| Uniprot primary ID | P29466 |
| PDB ID | 1BMQ 3D6H 1ICE 3NS7 2H48 1SC4 1SC1 1SC3 2FQQ 2HBY 2HBZ 2H4Y 2H4W 2HBQ 2HBR 1RWX 3D6F 1IBC 3E4C 1RWP 3D6M 1RWV 1RWW 1RWK 1RWM 1RWN 1RWO 2H51 2H54 |
| DrugBank ID | DB01017 |
| BioGrid ID | 107284 |
| GuidetoPHARMACOLOGY ID | 1617 |
| PharmGKB ID | PA26083 |
| KEGG ID | hsa:834 |
| DIP ID | DIP-175N |
| STRING ID | 9606.ENSP00000410076 |
| IntAct ID | P29466 |
| DMDM | 266321 |
| BRENDA | 3.4.22.36 |
| Reactome | R-HSA-844623 R-HSA-844615 R-HSA-448706 R-HSA-168638 R-HSA-844456 |
| SignaLink | P29466 |
| BioCyc | |
| Entrez Gene (Gene ID) | 834 |
| BindingDB | P29466 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.938 | 0.004 | 0.924 | 0.000 | 0.931 | 0.003 | 0.931 | 0.003 | 0.966 | 0.005 | 0.864 | 0.005 | Download |
| Estate fingerprints | 0.874 | 0.005 | 0.806 | 0.000 | 0.840 | 0.000 | 0.850 | 0.000 | 0.920 | 0.000 | 0.688 | 0.004 | Download |
| MACCS fingerprints | 0.880 | 0.000 | 0.860 | 0.005 | 0.870 | 0.000 | 0.870 | 0.000 | 0.930 | 0.000 | 0.741 | 0.006 | Download |
| Daylight fingerprints | 0.742 | 0.004 | 0.938 | 0.005 | 0.840 | 0.000 | 0.820 | 0.000 | 0.930 | 0.000 | 0.690 | 0.000 | Download |
| ECFP2 fingerprints | 0.920 | 0.000 | 0.958 | 0.005 | 0.939 | 0.003 | 0.938 | 0.004 | 0.980 | 0.000 | 0.876 | 0.005 | Download |
| ECFP4 fingerprints | 0.931 | 0.003 | 0.989 | 0.000 | 0.960 | 0.000 | 0.955 | 0.005 | 0.990 | 0.000 | 0.911 | 0.003 | Download |
| ECFP6 fingerprints | 0.940 | 0.000 | 0.980 | 0.000 | 0.960 | 0.000 | 0.960 | 0.000 | 0.990 | 0.000 | 0.927 | 0.005 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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