Target name

P29466: Caspase-1


  Protein function

Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.

  Database links

Uniprot primary ID P29466
PDB ID 1BMQ 3D6H 1ICE 3NS7 2H48 1SC4 1SC1 1SC3 2FQQ 2HBY 2HBZ 2H4Y 2H4W 2HBQ 2HBR 1RWX 3D6F 1IBC 3E4C 1RWP 3D6M 1RWV 1RWW 1RWK 1RWM 1RWN 1RWO 2H51 2H54
DrugBank ID DB01017
BioGrid ID 107284
GuidetoPHARMACOLOGY ID 1617
PharmGKB ID PA26083
KEGG ID hsa:834
DIP ID DIP-175N
STRING ID 9606.ENSP00000410076
IntAct ID