Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
| Uniprot primary ID | P29474 |
| PDB ID | 1M9M 4D1O 2MG5 1M9K 1M9J 1NIW 3EAH 2LL7 3NOS 1M9R 1M9Q 4D1P |
| DrugBank ID | DB00997 DB01110 DB00125 DB00360 DB00155 |
| BioGrid ID | 110909 |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | PA254 |
| KEGG ID | hsa:4846 |
| DIP ID | DIP-38479N |
| STRING ID | 9606.ENSP00000297494 |
| IntAct ID | P29474 |
| DMDM | 266648 |
| BRENDA | 1.14.13.39 |
| Reactome | R-HSA-1222556 R-HSA-203754 R-HSA-392154 R-HSA-203615 R-HSA-203641 R-HSA-1474151 R-HSA-5218920 |
| SignaLink | P29474 |
| BioCyc | MetaCyc:HS09149-MONOMER |
| Entrez Gene (Gene ID) | 4846 |
| BindingDB | P29474 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.873 | 0.008 | 0.911 | 0.007 | 0.892 | 0.004 | 0.891 | 0.006 | 0.970 | 0.000 | 0.786 | 0.010 | Download |
| Estate fingerprints | 0.836 | 0.008 | 0.894 | 0.005 | 0.865 | 0.005 | 0.861 | 0.006 | 0.911 | 0.003 | 0.730 | 0.007 | Download |
| MACCS fingerprints | 0.804 | 0.005 | 0.928 | 0.000 | 0.866 | 0.005 | 0.859 | 0.003 | 0.950 | 0.000 | 0.737 | 0.005 | Download |
| Daylight fingerprints | 0.662 | 0.006 | 0.858 | 0.000 | 0.760 | 0.000 | 0.733 | 0.005 | 0.830 | 0.000 | 0.529 | 0.003 | Download |
| ECFP2 fingerprints | 0.977 | 0.005 | 0.907 | 0.007 | 0.942 | 0.004 | 0.946 | 0.005 | 0.990 | 0.000 | 0.890 | 0.007 | Download |
| ECFP4 fingerprints | 0.998 | 0.004 | 0.948 | 0.003 | 0.973 | 0.005 | 0.974 | 0.005 | 1.000 | 0.000 | 0.951 | 0.007 | Download |
| ECFP6 fingerprints | 0.995 | 0.005 | 0.953 | 0.005 | 0.974 | 0.005 | 0.977 | 0.005 | 1.000 | 0.000 | 0.951 | 0.006 | Download |
| Positive dataset | Negative dataset |
The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
E-mail: jiedong@csu.edu.cn
 |
 |
 |
 |
 |
 |