TargetNet
  Target name

P29474: Nitric oxide synthase, endothelial

  Protein function

Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.

  Database links
Uniprot primary ID P29474
PDB ID 1M9M 4D1O 2MG5 1M9K 1M9J 1NIW 3EAH 2LL7 3NOS 1M9R 1M9Q 4D1P
DrugBank ID DB00997 DB01110 DB00125 DB00360 DB00155
BioGrid ID 110909
GuidetoPHARMACOLOGY ID
PharmGKB ID PA254
KEGG ID hsa:4846
DIP ID DIP-38479N
STRING ID 9606.ENSP00000297494
IntAct ID P29474
DMDM 266648
BRENDA 1.14.13.39
Reactome R-HSA-1222556 R-HSA-203754 R-HSA-392154 R-HSA-203615 R-HSA-203641 R-HSA-1474151 R-HSA-5218920
SignaLink P29474
BioCyc MetaCyc:HS09149-MONOMER
Entrez Gene (Gene ID) 4846
BindingDB P29474
  Model Performance Metrics
Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.873 0.008 0.911 0.007 0.892 0.004 0.891 0.006 0.970 0.000 0.786 0.010 Download
Estate fingerprints 0.836 0.008 0.894 0.005 0.865 0.005 0.861 0.006 0.911 0.003 0.730 0.007 Download
MACCS fingerprints 0.804 0.005 0.928 0.000 0.866 0.005 0.859 0.003 0.950 0.000 0.737 0.005 Download
Daylight fingerprints 0.662 0.006 0.858 0.000 0.760 0.000 0.733 0.005 0.830 0.000 0.529 0.003 Download
ECFP2 fingerprints 0.977 0.005 0.907 0.007 0.942 0.004 0.946 0.005 0.990 0.000 0.890 0.007 Download
ECFP4 fingerprints 0.998 0.004 0.948 0.003 0.973 0.005 0.974 0.005 1.000 0.000 0.951 0.007 Download
ECFP6 fingerprints 0.995 0.005 0.953 0.005 0.974 0.005 0.977 0.005 1.000 0.000 0.951 0.006 Download
  Download datasets
Positive dataset Negative dataset

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 E-mail: biomed@csu.edu.cn