Target name

P29475: Nitric oxide synthase, brain


  Protein function

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR.

  Database links

Uniprot primary ID P29475
PDB ID 4UH5 4D1N 4UH6 4UCH 4V3U
DrugBank ID DB00997 DB03147 DB00155
BioGrid ID 110905
GuidetoPHARMACOLOGY ID 1251
PharmGKB ID PA252
KEGG ID hsa:4842
DIP ID DIP-40999N
STRING ID 9606.ENSP00000337459
IntAct ID P29475
DMDM 1709333
BRENDA 1.14.13.39
Reactome R-HSA-1222556 R-HSA-392154
SignaLink
BioCyc MetaCyc:HS01647-MONOMER
Entrez Gene (Gene ID) 4842
BindingDB P29475

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.867 0.005 0.917 0.000 0.892 0.004 0.890 0.000 0.960 0.000 0.784 0.005 Download
Estate fingerprints 0.797 0.005 0.883 0.003 0.840 0.000 0.832 0.004 0.920 0.000 0.683 0.005 Download
MACCS fingerprints 0.810 0.005 0.876 0.000 0.843 0.005 0.840 0.000 0.940 0.000 0.692 0.004 Download
Daylight fingerprints 0.652 0.004 0.834 0.005 0.743 0.005 0.720 0.000 0.810 0.000 0.497 0.005 Download
ECFP2 fingerprints 0.960 0.000 0.942 0.003 0.951 0.003 0.951 0.003 0.990 0.000 0.905 0.005 Download
ECFP4 fingerprints 0.965 0.005 0.965 0.005 0.965 0.005 0.965 0.005 0.997 0.005 0.930 0.000 Download
ECFP6 fingerprints 0.953 0.005 0.977 0.003 0.965 0.005 0.965 0.005 0.990 0.000 0.932 0.004 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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