Target name

P29476: Nitric oxide synthase, brain


  Protein function

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum.

  Database links

Uniprot primary ID P29476
PDB ID 2G6K 2G6J 2G6I 2G6H 2G6N 2G6M 2G6L 4UH4 4CTU 4UH1 4UH0 4UH3 4UH2 4K5D 4K5E 4K5F 1F20 4CAQ 4CAM 4CAN 4CAO 4JSG 3JWU 1ZVI 4IMU 3B3N 3B3O 3B3M 3B3P 4GQE 1TLL 4HOP 4CX3 5AGK 3JWT 4V3X 5AGO 3JWS 5AGM 5AGL 4K5G 4UPM 4UPO 4UPN 3TYN 4JSE 4D2Y 4UPP 4C39 3JWV 3NNY
DrugBank ID
BioGrid ID 246738
GuidetoPHARMACOLOGY ID 1251
PharmGKB ID
KEGG ID rno:24598
DIP ID DIP-33272N
STRING ID 10116.ENSRNOP00000062735
IntAct ID P29476
DMDM
BRENDA 1.14.13.39
Reactome
SignaLink
BioCyc
Entrez Gene (Gene ID) 24598
BindingDB P29476

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.948 0.010 0.910 0.007 0.929 0.003 0.932 0.006 0.980 0.000 0.861 0.013 Download
Estate fingerprints 0.886 0.010 0.912 0.007 0.899 0.006 0.898 0.004 0.950 0.000 0.798 0.008 Download
MACCS fingerprints 0.879 0.007 0.917 0.005 0.898 0.006 0.897 0.005 0.960 0.000 0.800 0.008 Download
Daylight fingerprints 0.761 0.003 0.841 0.003 0.801 0.003 0.793 0.005 0.870 0.000 0.608 0.006 Download
ECFP2 fingerprints 0.917 0.007 0.945 0.003 0.931 0.003 0.931 0.003 0.980 0.000 0.866 0.005 Download
ECFP4 fingerprints 0.936 0.005 0.964 0.005 0.950 0.000 0.949 0.003 0.990 0.000 0.902 0.006 Download
ECFP6 fingerprints 0.941 0.007 0.967 0.005 0.954 0.005 0.954 0.005 0.990 0.000 0.911 0.010 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn