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E-mail: biomed@csu.edu.cn
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Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (By similarity).
| Uniprot primary ID | P29477 |
| PDB ID | 3EBF 2ORO 1QW5 1QW4 3EBD 3DWJ 3E67 3E65 3E68 3NOD 3E7M 1JWK 1DWV 1DWW 1DWX 3NQS 1DD7 3EAI 1M9T 1NOS 1DF1 3GOF 3NW2 2NOS 1NOD 1NOC 1QOM 2BHJ 2NOD 3E7T 3E7I 1JWJ 2ORT 2ORS 2ORR 2ORQ 2ORP 1R35 4UX6 1N2N 1M8D 1M8E 1VAF 2Y37 1M8H 1M8I 3E6N 3E6O 3E6L 3E6T 4JS9 |
| DrugBank ID | |
| BioGrid ID | 201806 |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | |
| KEGG ID | mmu:18126 |
| DIP ID | DIP-31080N |
| STRING ID | 10090.ENSMUSP00000018610 |
| IntAct ID | P29477 |
| DMDM | |
| BRENDA | 1.14.13.39 |
| Reactome | R-MMU-1222556 R-MMU-392154 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 18126 |
| BindingDB | P29477 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.914 | 0.007 | 0.878 | 0.003 | 0.896 | 0.005 | 0.900 | 0.005 | 0.941 | 0.003 | 0.793 | 0.008 | Download |
| Estate fingerprints | 0.883 | 0.008 | 0.925 | 0.009 | 0.904 | 0.005 | 0.904 | 0.005 | 0.922 | 0.004 | 0.810 | 0.009 | Download |
| MACCS fingerprints | 0.852 | 0.008 | 0.836 | 0.009 | 0.844 | 0.005 | 0.845 | 0.005 | 0.910 | 0.000 | 0.682 | 0.009 | Download |
| Daylight fingerprints | 0.780 | 0.009 | 0.848 | 0.000 | 0.814 | 0.005 | 0.806 | 0.005 | 0.850 | 0.000 | 0.630 | 0.009 | Download |
| ECFP2 fingerprints | 0.928 | 0.009 | 0.918 | 0.008 | 0.923 | 0.007 | 0.923 | 0.007 | 0.977 | 0.005 | 0.845 | 0.010 | Download |
| ECFP4 fingerprints | 0.961 | 0.009 | 0.927 | 0.010 | 0.944 | 0.005 | 0.944 | 0.005 | 0.980 | 0.000 | 0.888 | 0.013 | Download |
| ECFP6 fingerprints | 0.971 | 0.006 | 0.947 | 0.005 | 0.959 | 0.003 | 0.959 | 0.003 | 0.980 | 0.000 | 0.916 | 0.008 | Download |
| Positive dataset | Negative dataset |
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E-mail: biomed@csu.edu.cn
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