Target name

P29477: Nitric oxide synthase, inducible


  Protein function

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (By similarity).

  Database links

Uniprot primary ID P29477
PDB ID 3EBF 2ORO 1QW5 1QW4 3EBD 3DWJ 3E67 3E65 3E68 3NOD 3E7M 1JWK 1DWV 1DWW 1DWX 3NQS 1DD7 3EAI 1M9T 1NOS 1DF1 3GOF 3NW2 2NOS 1NOD 1NOC 1QOM 2BHJ 2NOD 3E7T 3E7I 1JWJ 2ORT 2ORS 2ORR 2ORQ 2ORP 1R35 4UX6 1N2N 1M8D 1M8E 1VAF 2Y37 1M8H 1M8I 3E6N 3E6O 3E6L 3E6T 4JS9
DrugBank ID
BioGrid ID 201806
GuidetoPHARMACOLOGY ID
PharmGKB ID
KEGG ID mmu:18126
DIP ID DIP-31080N
STRING ID 10090.ENSMUSP00000018610
IntAct ID P29477
DMDM
BRENDA 1.14.13.39
Reactome R-MMU-1222556 R-MMU-392154
SignaLink
BioCyc
Entrez Gene (Gene ID) 18126
BindingDB P29477

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.914 0.007 0.878 0.003 0.896 0.005 0.900 0.005 0.941 0.003 0.793 0.008 Download
Estate fingerprints 0.883 0.008 0.925 0.009 0.904 0.005 0.904 0.005 0.922 0.004 0.810 0.009 Download
MACCS fingerprints 0.852 0.008 0.836 0.009 0.844 0.005 0.845 0.005 0.910 0.000 0.682 0.009 Download
Daylight fingerprints 0.780 0.009 0.848 0.000 0.814 0.005 0.806 0.005 0.850 0.000 0.630 0.009 Download
ECFP2 fingerprints 0.928 0.009 0.918 0.008 0.923 0.007 0.923 0.007 0.977 0.005 0.845 0.010 Download
ECFP4 fingerprints 0.961 0.009 0.927 0.010 0.944 0.005 0.944 0.005 0.980 0.000 0.888 0.013 Download
ECFP6 fingerprints 0.971 0.006 0.947 0.005 0.959 0.003 0.959 0.003 0.980 0.000 0.916 0.008 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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