Details-Calcnet-TargetNet

Target name

P29597: Non-receptor tyrosine-protein kinase TYK2

Protein function

Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.

Database links

Uniprot primary ID	P29597
PDB ID	3LXP 4PY1 4GVJ 4GIH 4GII 4GJ3 4GJ2 3NYX 3NZ0 4GFO 3ZON 4OLI 4PO6 4WOV 5C01 5C03 3LXN
DrugBank ID
BioGrid ID	113148
GuidetoPHARMACOLOGY ID	2269
PharmGKB ID	PA37094
KEGG ID	hsa:7297
DIP ID	DIP-1062N
STRING ID	9606.ENSP00000264818
IntAct ID	P29597
DMDM	56405328
BRENDA	2.7.10.2
Reactome	R-HSA-112411 R-HSA-1059683 R-HSA-912694 R-HSA-110056 R-HSA-909733
SignaLink	P29597
BioCyc
Entrez Gene (Gene ID)	7297
BindingDB	P29597

Model Performance Metrics

Fingerprint type	Sensitivity	SEN_std	Specificity	SPE_std	Accuracy	ACC_std	F1-score	F1-score_std	AUC	AUC_std	MCC	MCC_std	Download model
FP2 fingerprints	0.654	0.008	0.868	0.009	0.761	0.007	0.733	0.008	0.866	0.005	0.533	0.016	Download
Estate fingerprints	0.832	0.011	0.620	0.013	0.726	0.013	0.750	0.011	0.821	0.006	0.462	0.023	Download
MACCS fingerprints	0.844	0.011	0.660	0.018	0.752	0.013	0.772	0.011	0.843	0.005	0.510	0.025	Download
Daylight fingerprints	0.788	0.004	0.726	0.011	0.757	0.007	0.766	0.007	0.818	0.006	0.515	0.011	Download
ECFP2 fingerprints	0.881	0.014	0.807	0.013	0.844	0.008	0.850	0.008	0.941	0.006	0.689	0.017	Download
ECFP4 fingerprints	0.825	0.010	0.903	0.010	0.864	0.011	0.859	0.009	0.941	0.003	0.726	0.015	Download
ECFP6 fingerprints	0.770	0.014	0.936	0.006	0.853	0.009	0.838	0.009	0.932	0.004	0.718	0.014	Download

Download datasets

Positive dataset

Negative dataset