Target name

P29597: Non-receptor tyrosine-protein kinase TYK2


  Protein function

Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.

  Database links

Uniprot primary ID P29597
PDB ID 3LXP 4PY1 4GVJ 4GIH 4GII 4GJ3 4GJ2 3NYX 3NZ0 4GFO 3ZON 4OLI 4PO6 4WOV 5C01 5C03 3LXN
DrugBank ID
BioGrid ID 113148
GuidetoPHARMACOLOGY ID 2269
PharmGKB ID PA37094
KEGG ID hsa:7297
DIP ID DIP-1062N
STRING ID 9606.ENSP00000264818
IntAct ID P29597
DMDM 56405328
BRENDA 2.7.10.2
Reactome R-HSA-112411 R-HSA-1059683 R-HSA-912694 R-HSA-110056 R-HSA-909733
SignaLink P29597
BioCyc
Entrez Gene (Gene ID) 7297
BindingDB P29597

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.654 0.008 0.868 0.009 0.761 0.007 0.733 0.008 0.866 0.005 0.533 0.016 Download
Estate fingerprints 0.832 0.011 0.620 0.013 0.726 0.013 0.750 0.011 0.821 0.006 0.462 0.023 Download
MACCS fingerprints 0.844 0.011 0.660 0.018 0.752 0.013 0.772 0.011 0.843 0.005 0.510 0.025 Download
Daylight fingerprints 0.788 0.004 0.726 0.011 0.757 0.007 0.766 0.007 0.818 0.006 0.515 0.011 Download
ECFP2 fingerprints 0.881 0.014 0.807 0.013 0.844 0.008 0.850 0.008 0.941 0.006 0.689 0.017 Download
ECFP4 fingerprints 0.825 0.010 0.903 0.010 0.864 0.011 0.859 0.009 0.941 0.003 0.726 0.015 Download
ECFP6 fingerprints 0.770 0.014 0.936 0.006 0.853 0.009 0.838 0.009 0.932 0.004 0.718 0.014 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

The recommended browsers: Safari, Firefox, Chrome, IE(Ver.>8).
 E-mail: biomed@csu.edu.cn