Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.
| Uniprot primary ID | P30291 |
| PDB ID | 3CR0 2IO6 2IN6 1X8B 2Z2W 3BIZ 3BI6 3CQE |
| DrugBank ID | |
| BioGrid ID | 113303 |
| GuidetoPHARMACOLOGY ID | 2278 |
| PharmGKB ID | PA366 |
| KEGG ID | hsa:7465 |
| DIP ID | DIP-37969N |
| STRING ID | 9606.ENSP00000402084 |
| IntAct ID | P30291 |
| DMDM | 1351419 |
| BRENDA | 2.7.10.2 |
| Reactome | R-HSA-69478 R-HSA-69656 R-HSA-156711 R-HSA-69202 R-HSA-75035 R-HSA-69273 R-HSA-983231 |
| SignaLink | P30291 |
| BioCyc | |
| Entrez Gene (Gene ID) | 7465 |
| BindingDB | P30291 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.912 | 0.004 | 1.000 | 0.000 | 0.960 | 0.000 | 0.952 | 0.004 | 0.970 | 0.000 | 0.912 | 0.004 | Download |
| Estate fingerprints | 0.920 | 0.000 | 0.942 | 0.004 | 0.931 | 0.003 | 0.931 | 0.003 | 0.970 | 0.000 | 0.869 | 0.003 | Download |
| MACCS fingerprints | 0.909 | 0.003 | 0.967 | 0.005 | 0.938 | 0.004 | 0.936 | 0.005 | 0.980 | 0.000 | 0.876 | 0.008 | Download |
| Daylight fingerprints | 0.863 | 0.009 | 0.995 | 0.000 | 0.929 | 0.006 | 0.924 | 0.005 | 0.980 | 0.000 | 0.868 | 0.008 | Download |
| ECFP2 fingerprints | 0.950 | 0.000 | 0.990 | 0.003 | 0.970 | 0.000 | 0.970 | 0.000 | 0.990 | 0.000 | 0.941 | 0.003 | Download |
| ECFP4 fingerprints | 0.930 | 0.000 | 1.000 | 0.000 | 0.970 | 0.000 | 0.970 | 0.000 | 0.990 | 0.000 | 0.940 | 0.000 | Download |
| ECFP6 fingerprints | 0.930 | 0.000 | 1.000 | 0.000 | 0.970 | 0.000 | 0.970 | 0.000 | 0.990 | 0.000 | 0.940 | 0.000 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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