Target name

P30291: Wee1-like protein kinase


  Protein function

Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.

  Database links

Uniprot primary ID P30291
PDB ID 3CR0 2IO6 2IN6 1X8B 2Z2W 3BIZ 3BI6 3CQE
DrugBank ID
BioGrid ID 113303
GuidetoPHARMACOLOGY ID 2278
PharmGKB ID PA366
KEGG ID hsa:7465
DIP ID DIP-37969N
STRING ID 9606.ENSP00000402084
IntAct ID P30291
DMDM 1351419
BRENDA 2.7.10.2
Reactome R-HSA-69478 R-HSA-69656 R-HSA-156711 R-HSA-69202 R-HSA-75035 R-HSA-69273 R-HSA-983231
SignaLink P30291
BioCyc
Entrez Gene (Gene ID) 7465
BindingDB P30291

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.912 0.004 1.000 0.000 0.960 0.000 0.952 0.004 0.970 0.000 0.912 0.004 Download
Estate fingerprints 0.920 0.000 0.942 0.004 0.931 0.003 0.931 0.003 0.970 0.000 0.869 0.003 Download
MACCS fingerprints 0.909 0.003 0.967 0.005 0.938 0.004 0.936 0.005 0.980 0.000 0.876 0.008 Download
Daylight fingerprints 0.863 0.009 0.995 0.000 0.929 0.006 0.924 0.005 0.980 0.000 0.868 0.008 Download
ECFP2 fingerprints 0.950 0.000 0.990 0.003 0.970 0.000 0.970 0.000 0.990 0.000 0.941 0.003 Download
ECFP4 fingerprints 0.930 0.000 1.000 0.000 0.970 0.000 0.970 0.000 0.990 0.000 0.940 0.000 Download
ECFP6 fingerprints 0.930 0.000 1.000 0.000 0.970 0.000 0.970 0.000 0.990 0.000 0.940 0.000 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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 E-mail: biomed@csu.edu.cn