Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity.
| Uniprot primary ID | P30305 |
| PDB ID | 1CWS 1CWR 1YM9 1CWT 4WH9 1YML 4WH7 2A2K 2UZQ 2IFD 1YS0 3FQT 3FQU 1YMK 1QB0 1YMD 2IFV |
| DrugBank ID | |
| BioGrid ID | 107429 |
| GuidetoPHARMACOLOGY ID | |
| PharmGKB ID | PA26260 |
| KEGG ID | |
| DIP ID | DIP-323N |
| STRING ID | 9606.ENSP00000245960 |
| IntAct ID | P30305 |
| DMDM | 21264471 |
| BRENDA | 3.1.3.48 |
| Reactome | R-HSA-69273 R-HSA-157881 R-HSA-69656 |
| SignaLink | |
| BioCyc | |
| Entrez Gene (Gene ID) | 994 |
| BindingDB | P30305 |
| Fingerprint type | Sensitivity | SEN_std | Specificity | SPE_std | Accuracy | ACC_std | F1-score | F1-score_std | AUC | AUC_std | MCC | MCC_std | Download model |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| FP2 fingerprints | 0.923 | 0.014 | 0.941 | 0.005 | 0.932 | 0.008 | 0.931 | 0.009 | 0.969 | 0.003 | 0.864 | 0.015 | Download |
| Estate fingerprints | 0.842 | 0.010 | 0.806 | 0.007 | 0.824 | 0.007 | 0.826 | 0.005 | 0.897 | 0.005 | 0.651 | 0.011 | Download |
| MACCS fingerprints | 0.846 | 0.005 | 0.862 | 0.005 | 0.854 | 0.005 | 0.854 | 0.005 | 0.920 | 0.000 | 0.711 | 0.006 | Download |
| Daylight fingerprints | 0.895 | 0.017 | 0.947 | 0.008 | 0.921 | 0.012 | 0.918 | 0.011 | 0.968 | 0.004 | 0.844 | 0.022 | Download |
| ECFP2 fingerprints | 0.967 | 0.005 | 0.925 | 0.005 | 0.946 | 0.005 | 0.947 | 0.005 | 0.980 | 0.000 | 0.893 | 0.012 | Download |
| ECFP4 fingerprints | 0.953 | 0.008 | 0.923 | 0.005 | 0.938 | 0.004 | 0.938 | 0.004 | 0.983 | 0.005 | 0.878 | 0.006 | Download |
| ECFP6 fingerprints | 0.942 | 0.004 | 0.938 | 0.003 | 0.940 | 0.000 | 0.940 | 0.000 | 0.982 | 0.004 | 0.881 | 0.003 | Download |
| Positive dataset | Negative dataset |
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E-mail: jiedong@csu.edu.cn
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