Target name

P30305: M-phase inducer phosphatase 2


  Protein function

Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Directly dephosphorylates CDK1 and stimulates its kinase activity. The three isoforms seem to have a different level of activity.

  Database links

Uniprot primary ID P30305
PDB ID 1CWS 1CWR 1YM9 1CWT 4WH9 1YML 4WH7 2A2K 2UZQ 2IFD 1YS0 3FQT 3FQU 1YMK 1QB0 1YMD 2IFV
DrugBank ID
BioGrid ID 107429
GuidetoPHARMACOLOGY ID
PharmGKB ID PA26260
KEGG ID
DIP ID DIP-323N
STRING ID 9606.ENSP00000245960
IntAct ID P30305
DMDM 21264471
BRENDA 3.1.3.48
Reactome R-HSA-69273 R-HSA-157881 R-HSA-69656
SignaLink
BioCyc
Entrez Gene (Gene ID) 994
BindingDB P30305

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.923 0.014 0.941 0.005 0.932 0.008 0.931 0.009 0.969 0.003 0.864 0.015 Download
Estate fingerprints 0.842 0.010 0.806 0.007 0.824 0.007 0.826 0.005 0.897 0.005 0.651 0.011 Download
MACCS fingerprints 0.846 0.005 0.862 0.005 0.854 0.005 0.854 0.005 0.920 0.000 0.711 0.006 Download
Daylight fingerprints 0.895 0.017 0.947 0.008 0.921 0.012 0.918 0.011 0.968 0.004 0.844 0.022 Download
ECFP2 fingerprints 0.967 0.005 0.925 0.005 0.946 0.005 0.947 0.005 0.980 0.000 0.893 0.012 Download
ECFP4 fingerprints 0.953 0.008 0.923 0.005 0.938 0.004 0.938 0.004 0.983 0.005 0.878 0.006 Download
ECFP6 fingerprints 0.942 0.004 0.938 0.003 0.940 0.000 0.940 0.000 0.982 0.004 0.881 0.003 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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