Target name

P30530: Tyrosine-protein kinase receptor UFO


  Protein function

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response.

  Database links

Uniprot primary ID P30530
PDB ID 4RA0 2C5D
DrugBank ID
BioGrid ID 107036
GuidetoPHARMACOLOGY ID 1835
PharmGKB ID PA25197
KEGG ID
DIP ID
STRING ID 9606.ENSP00000301178
IntAct ID P30530
DMDM 239938818
BRENDA 2.7.10.1
Reactome R-HSA-4420097
SignaLink P30530
BioCyc
Entrez Gene (Gene ID) 558
BindingDB P30530

  Model Performance Metrics

Fingerprint type Sensitivity SEN_std Specificity SPE_std Accuracy ACC_std F1-score F1-score_std AUC AUC_std MCC MCC_std Download model
FP2 fingerprints 0.773 0.009 0.895 0.008 0.834 0.007 0.824 0.007 0.904 0.005 0.672 0.018 Download
Estate fingerprints 0.778 0.015 0.754 0.017 0.766 0.008 0.769 0.007 0.849 0.003 0.531 0.017 Download
MACCS fingerprints 0.821 0.014 0.731 0.013 0.776 0.010 0.788 0.009 0.863 0.005 0.559 0.019 Download
Daylight fingerprints 0.772 0.008 0.818 0.014 0.795 0.008 0.792 0.006 0.851 0.006 0.593 0.016 Download
ECFP2 fingerprints 0.810 0.011 0.912 0.011 0.861 0.007 0.852 0.006 0.931 0.003 0.724 0.012 Download
ECFP4 fingerprints 0.800 0.005 0.940 0.008 0.870 0.005 0.859 0.006 0.950 0.005 0.747 0.014 Download
ECFP6 fingerprints 0.744 0.013 0.964 0.006 0.854 0.007 0.835 0.010 0.946 0.005 0.729 0.011 Download

  Download datasets

Positive dataset Negative dataset


Copyright @ 2012-2014 Computational Biology & Drug Design Group,
School of Pharmaceutical Sciences, Central South University. All rights reserved.

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 E-mail: biomed@csu.edu.cn